Here are some recent, relevant updates and themes in the medical literature about oral candidiasis (thrush)—mostly focused on risk factors in specific patient groups and emerging treatment directions:
- Higher risk in hospitalized people with COVID-19: A recent study of hospitalized adults with SARS‑CoV‑2 infection (March 2020–December 2022) reported an oral candidiasis incidence of 17.0%, and found that antibiotics and corticosteroids were associated with increased risk.[2]
- Possible links to COVID-related immunologic changes: Another review-like paper discusses how immunosuppression and inflammatory/immune changes in people with COVID-19 may favor Candida colonization and subsequent infection, with poor oral hygiene and iatrogenic causes also highlighted as risk factors.[4]
- Strain diversity and the role of steroid/antibiotic exposure: An observational report from the COVID era noted oral candidiasis cases occurring under corticosteroids and antimicrobial therapy, and it emphasizes that when isolates are clinically significant, antifungal susceptibility testing should be performed; it also cautions against overuse of steroids/antimicrobials that could contribute to disease.[5]
- Ongoing interest in improving therapy and overcoming limitations: A 2025 paper on treatment advances describes current limitations of therapy (e.g., toxicity/delivery challenges for some antifungals) and discusses new delivery strategies and formulations as potential directions to improve effectiveness and safety.[9]
If you want, I can narrow it
Tell me which angle you care about most:
1) COVID/hospital settings
2) HIV / immunocompromised patients
3) New treatments or drug delivery
4) Prevention guidance (e.g., dentures, inhaled steroids, diabetes control)
And if you share your context (age group, immune status, denture use, inhaled steroid use), I’ll pull together the most relevant “latest” takeaways.
Sources
Prophylaxis on either a daily or weekly basis with antifungals reduces the incidence of oral candidiasis in patients with HIV with the reductions being most marked in those with low CD4 counts and recurrent oral candidiasis.^63–66^ The use of a chlorhexidine rinse only in bone marrow transplant patients as prophylaxis was found to be very effective.^67^
academic.oup.comOral candidiasis, commonly referred to as “thrush,” is an opportunistic fungal infection that commonly affects the oral mucosa. The main causative agent, Candida albicans, is a highly versatile commensal organism that is well adapted to its human ...
pmc.ncbi.nlm.nih.govBackground: Oral candidiasis has been documented in patients with SARS-CoV-2 infection, with varying prevalence rates across geographic regions and patient demographics. This study aimed to ascertain the incidence, characteristics, and risk factors ...
pmc.ncbi.nlm.nih.govOral Candidiasis (OC) is an opportunistic fungal infection of the oral cavity, frequently reported under local and systemic predisposing circumstances. While the recurrence of OC HIV-infected subjects has been well described and reported, the ...
pmc.ncbi.nlm.nih.govThe Candida genus colonizes the oral mucosa of immunocompetent individuals and healthy people, which is maintained by the innate immune system. However, any disturbance in this relationship, such as immunodepression, can turn this normally harmless ...
pmc.ncbi.nlm.nih.govOral candidosis is the most common fungal infection that frequently occurs in patients debilitated by other diseases or conditions. No candidosis happens without a cause; hence oral candidosis has been branded as a disease of the diseased. Prior ...
pmc.ncbi.nlm.nih.govIntroductionThe occurrence of oral candidiasis (OC) is expected in patients with COVID-19, especially those with moderate to severe forms of infection who ar...
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